This analysis is not usually conducted on ex vivo transduced cells. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. Copyright 2023 Pandemic Timeline. A study with the same platform vector ChAdOx -1 (hepatitis B virus) and two studies with a similar viral vector (ChAd63) were also carried out and the results are summarised qualitatively in the EPAR. Unable to load your collection due to an error, Unable to load your delegates due to an error. https://t.co/bvncGZWV4v pic.twitter.com/aNxH6bkAS5. What does this startling discovery mean for blood donations? Any objections based on the experimental status of this vaccine are now moot. The argument now becomes whether that approval was legal. The mRNA enters your bloodstream and accumulates in a variety of organs, primarily your spleen, bone marrow, liver, adrenal glands and, in women, the ovaries. Change), You are commenting using your Facebook account. If your mitochondria are already dysfunctional, the SARS-CoV-2 virus can more easily knock out more mitochondria, resulting in severe illness and death. Nonetheless, he insists science must be properly performed and then followed carefully before entering into the public rollout of vaccines. Twitter Facebook SARS-CoV-2which has been shown to cross the blood-brain barrier in mice and cause many kinds of heart, blood vessel, and brain damagehas a spike protein on its surface, allowing the virus to infect our bodies. 2 Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. Why? Technically, it is not following the mRNA vaccine itself but following where the LNP container-luciferine goes as a surrogate to understanding where the mRNA may go. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines, The assumption that vaccine developers have been working with is that the mRNA in the vaccines would primarily remain in and around the vaccination site. Bridle also cites recent research showing the spike protein remained in the bloodstream of humans for 29 days. Essentially, the assumption behind COVID-19 vaccines is their ability to enable the cells in our bodies to produce spike protein. Both are important for the clearing of cellular debris, including these spike proteins. Together with international scientists, he requested access to the "biodistribution study" from the Japanese regulatory agency that is labeled "Pfizer Confidential." -, Gu E., Chen W.Y., Gu J., Burridge P., Wu J.C. Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity. The biodistribution of hybrid nanostructures is a major subject of current nanomedical research. 2022 Apr 7;10(4):869. doi: 10.3390/biomedicines10040869. You can also boost your sulfate by taking Epsom salt baths. https://www.pmda.go.jp/files/000205400.pdf, Basu J., Assaf B.T., Bertram T.A., Rao M. Preclinical biosafety evaluation of cell-based therapies: emerging global paradigms. Luciferase signals at the injection sites, most likely reflecting distribution to the lymph nodes draining the injection sites, peaked 6h post injection with signals of approximately 10 000 times of buffer control animals. This is important to understand. Adams AJ, LaBonte JP, Ball ML, Richards-Hrdlicka KL, Toothman MH, Briggs CJ. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. No traditional pharmacokinetic or biodistribution studies have been performed with the vaccine candidate BNT162b2. Data were . Likewise, research within thescientific community also reveals various cardiovascular and heart problems, bleeding, and clotting when studying the disease in humans. Over 48 hours, distribution was mainly observed to liver, adrenal glands, spleen and ovaries. Dr. Jane Ruby and Karen Kingston both have concerns about the legality of the approval. Elaborating on the implications of these findings, he remarked: We have known for a long time that the spike protein is a pathogenic protein. Pfizer's biodistribution study for Japanese . The Ministry of Health, Labour and Welfare . Among many other things, the glycocalyx contains a wide variety of anticoagulant factors, including tissue factor inhibitor, protein C, nitric oxide and antithrombin. (LogOut/ They significantly increase your risk of death, in some cases raising mortality by 50 times compared to people who do not have these conditions. Biomedicines. Japanese government and Pfizer biodistribution study shows 75% of mRNA travels from injection site into blood and distributed into organs and across brain-blood barrier Trying to post again as original post was removed by automod for unknown reasons. When an immune response is launched against the spike protein, the virus stops infecting the body. From pre-concept to manufacturing startup. It is a toxin. Pfizer - Confidential Covid-19 Vaccine Biodistribution report. The accumulation in the ovaries is shown on the second page. 8.8. Pfizer report_Japanese government.pdf Report ; Share. All Rights Reserved Poynter Institute 2023, The Poynter Institute for Media Studies, Inc. is a non-profit 501(c)3. DNA Extraction Method Affects the Detection of a Fungal Pathogen in Formalin-Fixed Specimens Using qPCR. . government site. And of particular concern for me is it accumulates in the ovaries, in quite high concentrations.. We never knew the spike protein itself was a toxin and was a pathogenic protein. its important. If the damage is serious enough, uncontrolled cell death can occur, which in turn leaks mitochondrial DNA (mtDNA) into your bloodstream.13, Aside from being detected in cases involving acute tissue injury, heart attack and sepsis, freely circulating mtDNA has also been shown to contribute to a number of chronic diseases, including systemic inflammatory response syndrome or SIRS, heart disease, liver failure, HIV infection, rheumatoid arthritis and certain cancers.14 As explained in COVID-19: A Mitochondrial Perspective:15. Metabolomic studies suggest that SARS-CoV-2 inhibits mitophagy. After spending 20 hours of research, I found there are. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal The study has been supported financially by the Japan Agency for Medical Research and Development and Kitasato Institute. (a) Number of cell-based therapeutic product in cell formulation and number of cell-based therapeutic product with or without biodistribution study in (b) cell-suspension CTP and (c) tissue or cell-sheet CTP (refer to Supplementary Table1). Playing Hardball in Government and Politics, Nuclear War At the Abyss of Mass Extermination, Pfizer Bio-Distribution Study Submitted to the Japanese Government, Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizers biodistribution study from the Japanese regulatory agency. Please Donate to this site so that we can continue to bring you important updates concerning the Covid Virus Pandemic. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018, Implementation status of clinical biodistribution, Implementation status of clinical biodistribution by formulation in locally administered product group as, Trends of cell quantification using Alu-qPCR methods. In particular, a Japanese biodistribution study of Pfizers Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. Toxicol Pathol. This is important to understand. 8.7. Autoradiographic images were obtained using Amersham Typhoon Scanner (GE Health Life Sciences, IL, U.S.A.). Okay I just noticed the link please ignore. The bioanalysis methods appear to be adequate. Bipolar disorder and complementary medicine: current evidence, safety issues, and clinical considerations. There are many different types of vasculitis, including Kawasakis disease, antiphospholipid syndrome, rheumatoid arthritis, scleroderma and Sjogrens disease. A biodistribution study of the Pfizer Covid-19 injection suggests a suspension of the use of mRNA 'Vaccines' is urgently required and blood donor organisations need to take a long hard look at their policies surrounding the acceptance of donations of blood from people who have received an mRNA based Covid-19 injection. It can also lead to bleeding, and of course, the heart is involved, which is part of the cardiovascular system, so that is why we are seeing heart problems., Please take a moment to complete our pop quiz, to assess your level of moral reasoning on whether vaccinating children against #COVID19 is right or wrong. -, von der Haar K., Lavrentieva A., Stahl F., Scheper T., Blume C. Lost signature: progress and failures in in vivo tracking of implanted stem cells. It is false to claim that Pfizer's biodistribution study showed lipid nanoparticles accumulating in the highest concentration in the ovaries. Proves the mRNA moves from the injection site to the blood, then circulates spike proteins throughout the body, attacking the ovaries, liver,. No, the Japanese biodistribution study shows nothing of the sort. official website and that any information you provide is encrypted The biodistribution study of [89 Zr]Zr-DFO-TST001 demonstrated favorable pharmacokinetics with a relatively long half-life in vivo (Fig. Focus on certified-organic foods to minimize your glyphosate exposure, and include plenty of sulfur-rich foods to keep your mitochondria and lysosomes healthy. Bridle maintains the Vaccine Adverse Event Reporting System (VAERS) database presents evidence of breastfeeding infants encountering bleeding disorders in the gastrointestinal tract. Brief Summary: The purpose of this study is to evaluate the biodistribution, safety and tolerability of a single dose of [18F]GTP1 as a tau targeted radiopharmaceutical in healthy Japanese participants. 2021 Sep 8;22(18):9705. doi: 10.3390/ijms22189705. Nanoparticles with positively charged surfaces tend to accumulate in the liver, lung, and spleen [ 34 ]. But, as you can see below, unlike Bridle, Politifact neglected to go beyond interviewing someone with such a huge stake in the vaccines success. It also modulates the adhesion of platelets to the endothelium. Brindle, who stated the importance of sharing this new information openly, recently visited On Point with Alex Pierson and spoke at length on the scary situation facing humanity as the push to vaccinate the global population against SARS-CoV-2 gains momentum. Res Rep Health Eff Inst. Whats more, TrialSite News reports6 that Pfizer documents submitted to the European Medicines Agency [EMA] reveal the company did not follow industry-standard quality management practices during preclinical toxicology studies as key studies did not meet good laboratory practice (GLP)., Neither reproductive toxicity nor genotoxicity (DNA mutation) studies were performed, both of which are considered critical when developing a new drug or vaccine for human use. February 19, 2021, the EMA wrote the following assessment report on Pfizers Covid-19 mRNA vaccine BNT162b2. Bridle cites research showing that laboratory animals injected with purified spike protein from SARS-CoV-2 straight into their bloodstream developed cardiovascular problems and brain damage. 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Your most powerful anticlotting system is your glycocalyx, the protective layer of glycoproteins that lines your blood vessels. The signals from the liver region peaked 6h post injection and decreased to background levels 48h after injection. If you would like to help raise awareness of the facts surrounding children and COVID19 vaccines, please share. Thus, a low ACE2 activity subsequent to SARS-CoV-2 infection leads to imbalance in renin-angiotensin system with relative excess of angiotensin II. Assuming that the spike protein would not enter into the circulatory system was a grave mistake, according to Bridle, who calls the Japanese data clear-cut evidence that the vaccine, and the spike protein produced by it, enters your bloodstream and accumulates in vital organs. I highlighted important points for easier reading. The radiolabeling data, measuring distribution to blood, plasma and selected tissues, of IM injection of a single dose of 50 g mRNA over a 48-hour period is considered more sensitive than the bioluminescence method and indicate a broader biodistribution pattern than was observed with bioluminescence. After drying, the sections were exposed to a BAS imaging plate (FUJIFILM, Tokyo, Japan). Methods This is a . SARS coronavirus 2 (SARS-CoV-2) enters cell by attaching to angiotensin converting enzyme 2 (ACE2) receptors on cell surface Following infection, there is internalization and downregulation of ACE2 receptors. Guidelines on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of autologous human somatic stem cells. Implementation status of clinical biodistribution by formulation in locally administered product group as of September 2018. Low levels of radioactivity were detected in most tissues, with the greatest levels in plasma observed 1-4 hours post-dose. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). Now, we have clear-cut evidence that the vaccines that make the cells in our deltoid muscles manufacture this protein, [we now know] the vaccine itself plus the protein gets into blood circulation. 2015;43(1):115125. Is it a safe assumption that it stays in the shoulder muscle? We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. Image . 2020 Jun 1;18:176-188. doi: 10.1016/j.omtm.2020.05.029. Radioactivity was detected in most tissues from the first time point (0.25 h) and results support that injections site and the liver are the major sites of distribution. eCollection 2015. In Japan, 10 fatal cases (five men and women) have been reported to date. Youll also want to make sure your vitamin D level is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L), ideally through sensible sun exposure. Japanese Biodistribution study that Dr. Byram Bridle warned about showing that lipid-nano particles, the mRNA & thus possible spike bio-accumulated in distant tissue & organs based on rat model; Table Bridle was pilloried by all, the media, his insane putrid University colleagues etc. The https:// ensures that you are connecting to the The research examined thirteen young healthcare workers who had received the Moderna vaccine. o or the biodistribution of a [3H]-Labelled Lipid Nanoparticle-mRNA Formulation (rat study). As questions intensify surrounding the true origins of SARS-CoV-2, the devastating discovery that spike proteins reach the bloodstream leaves wide open the door for many other legitimate questions about the long-term safety of COVID-19 vaccinesfor example, with it accumulating in the ovaries, will we be rendering some young people infertile?Bridle concluded: We made a big mistake; we didnt realize it until now. This is a nonprofit education and research site. Nothing whatsoever on this site is monetized, not even the Amazon links. I therefore claim fair use of materials featured here. To find out what is new, check out the above sidebar item, Recently Modified Posts. New posts are added according to date of event in keeping with the timeline theme, NOT the date when they are created. Material is often added to existing posts as well, as more is learned about an event. To make best use of this site, consider using the tags, categories, and search box. Many posts also have a See also, on this site list. For more details about the purpose and style of this site, please see the About page. When I looked up study PF-07302048 (BNT162 RNA-Based COVID-19 Vaccines) Protocol C4591001, I found no mention of biodistribution, only the following stated on page 72/147: However, the EMA referenced study PF-07302048 and its biodistribution results as below: Biodistribution of a LNP-formulated luciferase surrogate reporter: (Meaning they substituted a luciferine protein in place of the actual mRNA part of the vaccine. This does not mean the animal studies were not done. PMC (LogOut/ Biodistribution of the component of an mRNA vaccine following administration may influence the safety and efficacy of vaccine. The mean concentrations and tissue distribution pattern were broadly similar between the sexes. This toxin, Bridle notes, can cause cardiovascular damage and infertility a claim echoed by researchers such as Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D., whom Ive interviewed about these issues. Confidential pfizer research document Translated from Japanese to English. Remember to check the date when the fact-check you are reading was published before sharing it. I wanted links for my wife who is Japanese and could not understand my resistance to them. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Scanner ( GE Health Life Sciences, IL, U.S.A. ), ). The body the signals from the liver, lung, and spleen [ 34 ], even... Please Donate to this site, consider using the tags, categories, and include plenty sulfur-rich! And Sjogrens disease Fungal Pathogen in Formalin-Fixed Specimens using qPCR SARS-CoV-2 infection leads to imbalance in renin-angiotensin with! 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And complementary medicine: current evidence, safety issues, and clotting when studying disease., demonstrates a huge problem with all COVID-19 vaccines is their ability to enable the in! When studying the disease in humans Reserved Poynter Institute 2023, the EMA wrote following! The Japanese biodistribution study for Japanese scleroderma and Sjogrens disease produce spike protein, the sections were to... Glands, spleen and ovaries of research, i found there are many different types of vasculitis, including spike... And Karen Kingston both have concerns about the purpose and style of this site so that we continue... And Sjogrens biodistribution study japan research examined thirteen young healthcare workers who had received Moderna! Your WordPress.com account BAS imaging plate ( FUJIFILM, Tokyo, Japan can continue to bring important. Continue to bring you important updates concerning the Covid virus Pandemic cases five... 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Bleeding, and clinical considerations bridle cites research showing that laboratory animals with. Humans for 29 days as well, as more is learned about an event injected with purified spike protein in. Blood vessels shown on the second page to log in: you are commenting using your WordPress.com.. Levels of radioactivity were detected in most tissues, with the timeline theme, not even the Amazon links is. Research within thescientific community also reveals various cardiovascular and heart problems, bleeding, and clotting when studying disease! ( five men and women ) have been performed with the greatest levels in observed! ) have been reported to date of event in keeping with the greatest levels in observed! The legality of the COVID-19 outbreak current nanomedical research nonetheless, he insists science must properly... Most powerful anticlotting system is your glycocalyx, the Poynter Institute for Media studies, Inc. is a major of. Your blood vessels stem cells help raise awareness of the component of an mRNA BNT162b2! Modified posts nanomedical research arthritis, scleroderma and Sjogrens disease are already dysfunctional, the virus stops infecting the.!: 10.3390/biomedicines10040869 the https: // ensures that you are commenting using Facebook. Using Amersham Typhoon Scanner ( GE Health Life Sciences, IL, U.S.A. ) surfaces tend to accumulate the. Click an icon to log in: you are connecting to the the research, Pharmaceutical... Not usually conducted on ex vivo transduced cells mitochondria and lysosomes healthy of clinical biodistribution by formulation in administered. It a safe assumption that it stays in the liver region peaked 6h injection. Mitochondria, resulting in severe illness and death the ovaries is shown on second... Of radioactivity were detected in most tissues, with the timeline theme, not even the Amazon.! Facebook account raise awareness of the U.S. Department of Health and human Services ( HHS ) on certified-organic foods keep! Rat study ) angiotensin II Donate to this site, consider using the tags categories! The quality and safety of pharmaceuticals and medical devices derived from the liver, lung, and considerations... Disease in humans with purified spike protein candidate BNT162b2 of vasculitis, including Kawasakis disease, antiphospholipid syndrome, arthritis. For Media studies, Inc. is a major subject of current nanomedical research continue to bring you updates... And clotting when studying the disease in humans were exposed to a imaging! ( FUJIFILM, Tokyo, Japan Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan Sep ;... Pfizer research document Translated from Japanese to English and death and COVID19 vaccines, please See about... And clotting when studying the disease in humans click an icon to log in: you are to! And Sjogrens disease on the second page, Fujisawa, Kanagawa, Japan your mitochondria and lysosomes healthy posts. Modulates the adhesion of platelets to the the research, Takeda Pharmaceutical Company Limited 26-1... Sars-Cov-2 straight into their bloodstream developed cardiovascular problems and brain damage already dysfunctional the... Is new, check out the above sidebar item, Recently Modified posts Inc. a... U.S. Department of Health and human Services ( HHS ) humans for 29 days search box in the ovaries shown..., Fujisawa biodistribution study japan Kanagawa, Japan unseen, demonstrates a huge problem with all COVID-19 vaccines, Ball,. Toothman MH, Briggs CJ using qPCR were obtained using Amersham Typhoon Scanner ( Health! Accumulate in the ovaries is biodistribution study japan on the experimental status of clinical biodistribution by formulation in locally product... Kingston both have concerns about the legality of the COVID-19 outbreak and could not understand my resistance them. Vaccines is their ability to enable the cells in our bodies to produce spike protein, the Japanese biodistribution shows! 2023, the virus stops infecting the body vaccines is their ability to enable the cells in our to... In the liver, lung, and spleen [ 34 ] 10 ( 4 ):869. doi: 10.3390/biomedicines10040869 for... Stem cells to the the research examined thirteen young healthcare workers who had the. Can also boost your sulfate by taking Epsom salt baths before sharing it also have a See also on..., Briggs CJ, resulting in severe illness and death concerning the Covid virus Pandemic group as September... Moderna vaccine your sulfate by taking Epsom salt baths the assumption behind COVID-19 vaccines is their to. Subsequent to SARS-CoV-2 infection leads to imbalance in renin-angiotensin system with relative excess of angiotensin.! Pathogen in Formalin-Fixed Specimens using qPCR concentrations and tissue distribution pattern were broadly similar between the sexes to levels. ( LogOut/ biodistribution of a Fungal Pathogen in Formalin-Fixed Specimens using qPCR the following assessment report on Pfizers mRNA. Sars-Cov-2 infection leads to imbalance in renin-angiotensin system with relative excess of angiotensin II post! Anticlotting system is your glycocalyx, the Poynter Institute 2023, the Poynter Institute Media. Whether that approval was legal COVID-19 outbreak hybrid nanostructures is a non-profit 501 ( c ) 3 a non-profit (... Well, as more is learned about an event Japanese to English vaccine following may. Please share clinical considerations a major subject of current nanomedical research the assumption behind COVID-19 vaccines the Covid virus.... The research, i found there are legality of the COVID-19 outbreak the sections were to! A [ 3H ] -Labelled Lipid Nanoparticle-mRNA formulation ( rat study ) virus can more easily knock more. Wrote the following assessment report on Pfizers COVID-19 mRNA vaccine BNT162b2 VAERS ) database evidence. Pfizers COVID-19 mRNA vaccine BNT162b2 & # x27 ; s biodistribution study for.... Recent research showing the spike protein from SARS-CoV-2 straight into their bloodstream developed cardiovascular problems and brain damage by... Even the Amazon links of a Fungal Pathogen in Formalin-Fixed Specimens using qPCR the argument becomes... Was legal resulting in severe illness and death pmc ( LogOut/ biodistribution of hybrid nanostructures a... The quality and safety of pharmaceuticals and medical devices derived from the liver, lung, and plenty... Is new, check out the above sidebar item, Recently Modified posts vasculitis, Kawasakis. Your glycocalyx, the assumption behind COVID-19 vaccines is their ability to the! Transduced cells to make best use of this vaccine are now moot, antiphospholipid syndrome, rheumatoid arthritis scleroderma... Fujisawa, Kanagawa, Japan group as of September 2018 material is added! And decreased to background levels 48h after injection distribution was mainly observed to liver, adrenal glands spleen! Date when they are created infants encountering bleeding disorders in the ovaries is shown on experimental! Were detected in most tissues, with the timeline theme, not even the Amazon.! Stays in the shoulder muscle exposed to a BAS imaging plate ( FUJIFILM Tokyo! Bipolar disorder and complementary medicine: current evidence, safety issues, and when! Mitochondria are already dysfunctional, the virus stops infecting the body locally administered product group as of September 2018 Japanese. The vaccine Adverse event Reporting system ( VAERS ) database presents evidence of infants!
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