Ondansetron is not a drug that stimulates gastric or intestinal peristalsis; should not be used instead of nasogastric suction. Ondansetron injection for the treatment of post-operative nausea and vomiting has been reported to cause drowsiness or sedation in 8% of patients vs. 7% of those using a placebo (an inactive . Ondansetron side effects. ( 3) CONTRAINDICATIONS Patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. In dogs, the usual dose is 0.05 to 0.5 mg per pound (0.1 to 1.0 mg/kg) orally every 12 to 24 hours. Ondansetron is a specific 5HT 3 -receptor antagonist which blocks 5HT 3 receptors in the gastro-intestinal tract and in the CNS. Order for patient CC reads, "ondansetron 4mg subcutaneously once as loading dose, then infuse subcutaneously at a continuous rate of .5mg/hr with a bolus dose 0.25mg every 30 minutes as needed for nausea/vomiting." Ondansetron solution for injection is available in 2mg/mL vials and 32mg/50mL premixed bags with dextrose 5% Before using Ondansetron Injection, inform your doctor about your current list of medications, over the counter products (e.g. ( 3 ) CONTRAINDICATIONS Patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. The administration duration also varies depending on the condition to be treated, the response and any side effects noted. In cats, the usual dose is 0.11 mg per pound (0.22 mg/kg) every 8 to 12 hours. or Intramuscular (I.M.) Caution: Dilution of Ondansetron Injection is required in adult and pediatric patients prior to administration. The recommended adult intravenous dosage of ZOFRAN is three .15-mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY]. vitamins, herbal supplements, etc. numbness and tingling. Injection: The recommended I.V. A second and third dose of ondansetron are sometimes given 4 hours and 8 hours after the first dose. Hope it works well for your Bostie! Dosage may be repeated twice, administered 4 and 8 hours after the initial dose. Caution: Dilution of Zofran Injection is required in adult and pediatric patients prior to administration. If you are using the premixed bags, after removing the bag from the outer wrapper, check for small leaks by squeezing the container firmly. Usual Adult Dose of Ondansetron for Nausea/Vomiting -- Postoperative: Oral:-Recommended dose: 16 mg orally 1 hour before the induction of anesthesia . Serotonin syndrome reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs including SSRIs, SNRIs, MAO inhibitors, lithium, tramadol . Ondansetron may cause serious side effects. Multiday, single-dose administration of a 24 mg dosage has not been studied. Prevention of Postoperative Nausea and/or Vomiting Ondansetron Injection Warnings/Precautions: <4 months of age (monitor closely). Not a substitute for nasogastric suction in gastric or intestinal peristalsis. Ondansetron Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin. By rectum Adult elevated liver function test results. Ondansetron injection is used to prevent nausea and vomiting caused by cancer medicines (chemotherapy or radiation), including high-dose cisplatin. Chemotherapy that causes moderate nausea and vomiting: 8 mg dose taken 30 minutes before the start of chemotherapy, with another 8 mg dose taken 8 hours after the first dose. WHAT IS Ondansetron? Injection-site pain (4%) . More typical pregnancy nausea is managed by a much . This means that Zofran injection contains 7 mg of sodium per 4 mg dose. Post-op (do not dilute): Infuse in not less than 30 seconds, preferably over 2-5 mins: 4mg IV as single dose immediately before induction of anesthesia; or shortly post-op if nausea or vomiting occurs. Onset 2 MG Injection is an antiemetic medicine used to treat and prevent nausea and vomiting caused by surgery, cancer medicines (chemotherapy) or radiation therapy. and in patients taking other medicinal products (e.g., ondansetron) or with other medical conditions known to prolong the QT interval . Call your doctor at once if you have: headache with chest pain and severe dizziness, fainting . Doses of Ondansetron Injection, USP (2 mg/mL): 2 mL single dose vial and 20 mL multiple dose vial. Ondansetron injection should be clear and colorless. ( 4, 7.2) WARNINGS AND PRECAUTIONS Ondansetron, marketed under the brand name Zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. Ondansetron Injection is indicated for the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin. ), allergies, pre-existing diseases, and current health conditions (e.g. Ondansetron Injection, USP (2 mg/mL): 2 mL Prefilled disposable single-dose syringe. This medicine is also used to prevent and treat nausea and vomiting that may happen after surgery. The plasma concentration-time profiles for nasal . The recommended dosage for adult and pediatric patients 6 months of age and older for prevention of nausea and vomiting associated with emetogenic chemotherapy is .15mg/kg per dose for 3 doses (maximum of 16 mg per dose). Read more Did you find an answer to your question? Dosage Forms And Strengths. Our scientific content is evidence-based, scientifically balanced and . Pediatric Use If you are on a low sodium diet, speak to your doctor, nurse or pharmacist before you have Zofran injection. Nausea and vomiting associated with cancer chemotherapy- 24 mg as a single. Ondansetron is usually given just before your surgery begins, or within 2 hours after surgery. It works by blocking a natural substance called serotonin in the brain that causes nausea and vomiting. Take the. Ondansetron Injection, USP 2 mg per mL is a clear, colorless, nonpyrogenic, sterile solution available as a 2 mL single-dose vial and 20 mL multi-dose vial. Adults: The recommended adult intravenous dosage of ZOFRAN is three .15-mg/kg doses up to a maximum of 16 mg per dose. The recommended dosage for adult and pediatric patients 6 months of age and older for prevention of nausea and vomiting associated with emetogenic chemotherapy is 0.15 mg/kg per dose for 3 doses (maximum of 16 mg per dose). Zofran Solution for Injection or Infusion contains sodium citrate and sodium chloride. More common side effects The more common side effects of ondansetron can include: headache. Learn how to store and discard medical supplies safely.To prevent or treat nausea after surgery, a single dose of ondansetron may be given undiluted into a muscle or vein (IV) shortly before the start of surgery, during surgery, or after surgery by a health care professional.Dosage is based on your weight, medical condition, and response to . 3 How to have Zofran Solution for Injection or Infusion The dose of Zofran for hyperemesis gravidarum requiring hospitalization is a maximum of 10 milligrams via intravenous therapy (IV) every 8 hours. Oral: Prevention of post-op nausea and vomiting- 16 mg 1 hour before anesthesia. A dose of 1 mg/kg OND (Zofran injection, 2 mg/mL) was administered to male Sprague-Dawley rats intravenously or intranasally. . Ondansetron Injection is approved for patients aged 6 months and older. I had a dog who needed it a good 8 months or more of every year and it never caused any trouble. injection-site pain. Severe hepatic dysfunction: max 8mg/day. Follow your doctor's dosing instructions very carefully. Mean bioavailability in healthy subjects, following administration of a single 8-mg tablet, is approximately 56%. Ondansetron Injection, USP, 2 mg/mL is a clear, colorless, nonpyrogenic, sterile solution available as a 2 mL single-dose vial and 20 mL multiple-dose vial. Adults: The recommended adult intravenous dosage of ondansetron is three 0.15 mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY (12.2)]. . Nausea and Vomiting Adult: PO 8 mg 30 min before chemotherapy, then q8h times 2 more doses Adult/ Child: IV 6 mo-18 y, 0.15 mg/kg or 32 mg infused over 15 min beginning 30 min before start of chemotherapy, followed by 0.15 mg/kg 4 and 8 h after first dose of ondansetron, may also give 8 mg bolus, then 1 mg/h by continuous infusion (max: 32 mg/d), or 32 mg as single dose ZOFRAN Injection should be diluted in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration. FDA previously issued a DSC about the ongoing safety review of ondansetron in September 2011. This medicine starts to work in 30 minutes. Intravenous dosage Adults 0.15 mg/kg (150 mcg/kg) IV infused over 15 minutes beginning 30 minutes prior to the initiation of emetogenic chemotherapy. Ondansetron Injection should be diluted in 50 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration. The nasal cavity can be a potential alternative route. The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Dosing will be based on weight. Using it for only the summer months should be no problem at all. What is the dosage of Ondansetron? US Brand Name. Maximum dose: 16 mg (per dose) Comments: The injection formulation should be diluted in 50 mL prior to IV administration. The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy. ( 4) Concomitant use of apomorphine. No single dose should exceed 16 mg/dose IV. For patients receiving highly emetogenic chemotherapy, eg. Emetogenic chemotherapy and radiotherapy For patients receiving emetogenic chemotherapy or radiotherapy ondansetron can be given either by intravenous or other routes of administration, however this product is for intravenous use only. highdose cisplatin, ondansetron may be administered as a single 8mg intravenous or intramuscular dose by slow intravenous injection in not less than 30 seconds, or intramuscular injection, immediately before chemotherapy. The recommended dosage of ondansetron is generally in the range of 0.05 to 0.5mg per pound of the body weight of the pet . pregnancy, upcoming surgery, etc. To prevent nausea and vomiting caused by chemotherapy, ondansetron is given 30 minutes before the start of chemotherapy. ondansetron 1 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen 00078067919 zofran odt 4 mg tablet 08/30/2017 12/31/2019 j9214 injection, interferon, alfa-2b, recombinant, 1 million units 00085111001 Other side effects of Ondansetron include: Cardiac. (2.4) Get emergency medical help if you have any of these signs of an allergic reaction: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Indications and dose Moderately emetogenic chemotherapy or radiotherapy By mouth Adult Initially 8 mg, dose to be taken 1-2 hours before treatment, then 8 mg every 12 hours for up to 5 days. Common side effects of Onset 2 MG Injection are constipation, headache and dizziness. Ondansetron HCl is a white to off-white powder that is soluble in water and normal saline. ZOFRAN Injection Dosage Intravenous Infusion Rate ; Adults > 12 yrs ; 4 mg x 1 : over 2 - 5 min : Pediatrics (> 40 kg) 4 mg x 1 ; over 2 - 5 min : Pediatrics ( 40 kg) 0.1 mg/kg x 1 : over 2 - 5 min In patients with severe hepatic impairment, a total daily dose of 8 mg should not be exceeded. Ondansetron is well absorbed from the gastrointestinal tract and undergoes some first-pass metabolism. Ondansetron Injection is approved for patients aged 6 months and older. Additional doses may be given 4 hours after the first dose of ondansetron and 8 hours after the first dose of ondansetron, if needed. 1.2 Prevention of Postoperative Nausea and/or Vomiting The dose range of ondansetron solution for injection or infusion is 8-32 mg a day and selected as shown below. ( 4 ) Concomitant use of apomorphine. Adults: The recommended adult intravenous dosage of Ondansetron is three .15-mg/kg doses up to a maximum of 16 mg per dose. (4, 7.2) WARNINGS AND PRECAUTIONS Yes No 4 CONTRAINDICATIONS Local: Injection site reaction (IV: 4%; includes burning sensation at injection site, erythema at injection site, injection site pain) . Drug information provided by: IBM Micromedex. 4 CONTRAINDICATIONS Ondansetron injection is contraindicated for patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. Or, may use 4mg IM undiluted as a single injection. Read More 3 DOSAGE FORMS AND STRENGTHS Ondansetron Injection, USP, 2 mg/mL is a clear, colorless, nonpyrogenic, sterile solution available as a 2 mL single-dose vial and 20 mL multiple-dose vial. May mask progressive ileus and/or gastric distention. Administration: Each 1 mL of aqueous solution in the 2-mL single-dose vial contains 2 mg of ondansetron as the hydrochloride dihydrate; 9.0 mg of sodium chloride, USP; and 0.5 mg of citric acid
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