Although sometimes defined as "an electronic version of a printed book", some e-books exist without a printed equivalent. The trials tested the drugs tucatinib and trastuzumab deruxtecan in women who had been previously treated for metastatic breast cancer that overproduces the HER2 protein, known as HER2-positive breast cancer.In one of the Secondary Outcome Measures : . Two new treatment options are emerging for women with metastatic breast cancer, following positive results from clinical trials. Check out the latest breaking news videos and viral videos covering showbiz, sport, fashion, technology, and more from the Daily Mail and Mail on Sunday. About Breast Cancer and HER2 Expression Breast cancer is the most common cancer and is one of the leading causes of cancer-related deaths worldwide. This approval is based on DESTINY-Breast04, a randomized, multicenter, open label clinical trial that enrolled 557 adult patients with unresectable or metastatic HER2-low breast cancer. The drug, trastuzumab deruxtecan (T-DXd), was approved based on a clinical trial led by Memorial Sloan Kettering Cancer Center (MSK) breast medical oncologist Shanu Modi. Background: Trastuzumab emtansine is the current standard treatment for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer whose disease progresses after treatment with a combination of anti-HER2 antibodies and a taxane. Studies for patients whose primary cancer site originated in the breast. In a phase I trial, patients with HER2-mutated NSCLC who received trastuzumab deruxtecan had a confirmed ORR of 72.7% (8/11) . The benefit shown in DESTINY-Breast04 was significant for those patients with advanced breast cancers that have become resistant to other treatmentspatients who have very few options. Based on the promising results of the DESTINY-Breast04 trial, clinicians are starting to differentiate levels of HER2 expression and redefine how metastatic breast cancer is classified with a distinct HER2-low patient population that may be eligible for trastuzumab deruxtecan. NPJ Breast Cancer. Select a clinical trial below to learn more. Expand your Outlook. Trastuzumab deruxtecan was also better at shrinking tumors, the DESTINY-Breast03 trial found. We've developed a suite of premium Outlook features for people with advanced email and calendar needs. Trastuzumab deruxtecan has shown activity in HER2-low breast cancer 33 and preclinically in cells with varying levels of HER2 expression. Nearly 90% of participants had hormone receptor positive disease, meaning their tumors had receptors for the hormones estrogen and/or progesterone. The phase 2, single-group DESTINY-Breast01 study showed that trastuzumab deruxtecan has durable antitumor activity in heavily pretreated patients with HER2-positive metastatic breast cancer. The phase 2, single-group DESTINY-Breast01 study showed that trastuzumab deruxtecan has durable antitumor activity in heavily pretreated patients with HER2-positive metastatic breast cancer. A Microsoft 365 subscription offers an ad-free interface, custom domains, enhanced security options, the full desktop version of In a clinical trial called DESTINY-Breast04, trastuzumab deruxtecan (brand name Enhertu) proved to be more successful than clinical trial leaders expected. Disease-free Survival (DFS) in Participants Who Were Administered Trastuzumab Deruxtecan (T-DXd) Compared With Trastuzumab Emtansine (T-DM1) Treatment [ Time Frame: Randomization to date of the first occurrence of an IDFS event including second primary non-breast cancer event or contralateral or ipsilateral ductal In this patient population, the percentage of patients with an overall response has ranged from 37.0 to 37.5%, and the median progression-free survival has ranged from 6.3 to 11.1 months. is defined as the length of time patients are alive after their initial diagnosis of cancer. Now we have a new way to target HER2 low, and patients have choices when it comes to their breast cancer treatment. A Phase 2, Multicenter, Open-Label Study of DS-8201a, an Anti-HER2-Antibody Drug Conjugate (ADC) for HER2-Positive, Unresectable and/or Metastatic Breast Cancer Subjects Previously Treated With T-DM1 (DESTINY-Breast01) Actual Study Start Date : August 25, 2017: Actual Primary Completion Date : March 21, 2019: Estimated Study Completion Date : The clinical trial, called DESTINY-Breast04, enrolled 557 adults who had metastatic or inoperable HER2-low breast cancer and had previously been treated with one or two types of chemotherapy. (Funded by Daiichi Sankyo and AstraZeneca; DESTINY-Breast04 ClinicalTrials.gov number, N On August 5, 2022, the FDA approved the first targeted therapy for patients with HER2-low breast cancer that has spread to other parts of the body and is unable to be surgically removed. Positive high-level results from the DESTINY-Breast02 Phase III trial of Enhertu (trastuzumab deruxtecan) versus physicians choice of treatment showed the trial met the primary endpoint, demonstrating a statistically significant and clinically meaningful improvement in progression-free survival (PFS) in patients with HER2-positive unresectable and/or metastatic On independent adjudication, the trial drug was associated with interstitial lung disease in 13.6% of the patients (grade 1 or 2, 10.9%; grade 3 or 4, 0.5%; and grade 5, 2.2%). DirecTV Pleads with Nexstar-Controlled Stations - Let's Settle This After the Election Season Bonanza With mid-term political ads rolling in at a record-breaking pace, pay TV operator extends olive branch to try to at least delay blackouts In a phase 3 trial, the antibodydrug conjugate trastuzumab deruxtecan resulted in longer survival than the physicians choice of chemotherapy among patients with HER2-low breast cancer. Find research articles on breast cancer, which may include news stories, clinical trials, blog posts, and descriptions of active Trastuzumab deruxtecan improved survival and shrank many tumors in the DESTINY-Breast01 trial, which led to its accelerated approval. Find latest news from every corner of the globe at Reuters.com, your online source for breaking international news coverage. In this trial involving patients with HER2-low metastatic breast cancer, trastuzumab deruxtecan resulted in significantly longer progression-free and overall survival than the physician's choice of chemotherapy. Conclusions: Trastuzumab deruxtecan showed durable antitumor activity in a pretreated patient population with HER2-positive metastatic breast cancer. In people with metastatic HER2-positive breast cancer, the targeted drug trastuzumab deruxtecan (Enhertu) markedly lengthened progression-free survival compared with trastuzumab emtansine (Kadcycla), new study results show. A Phase 3, Multicenter, Randomized, Open-label, Active Controlled Trial of DS-8201a, an Anti-HER2-antibody Drug Conjugate (ADC), Versus Treatment of Physician's Choice for HER2-low, Unresectable and/or Metastatic Breast Cancer Subjects: Actual Study Start Date : December 27, 2018: Estimated Primary Completion Date : January 1, 2023 Not monitored 24/7. Phase III Study of Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive, First-line Metastatic Breast Cancer (DESTINY-Breast09) Actual Study Start Date : April 26, 2021: Estimated Primary Completion Date : December 30, 2024: Estimated Study Completion Date : December 30, 2029 DESTINY-Breast05 TRIAL OVERVIEW Official Title: A Phase 3 , Multicenter of Trastuzumab Deruxtecan (T-DXd) in Combination With Other Anti-cancer Agents in Patients With Metastatic HER2-low Breast Cancer (DESTINY-Breast08) Methods: We conducted a phase 3, multicenter, open-label, randomized trial to compare the An ebook (short for electronic book), also known as an e-book or eBook, is a book publication made available in digital form, consisting of text, images, or both, readable on the flat-panel display of computers or other electronic devices. Advice for HER2 low breast cancer patients. Keep up with City news, services, programs, events and more. DS-8201a Versus T-DM1 for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive, Unresectable and/or Metastatic Breast Cancer Previously Treated With Trastuzumab and Taxane [DESTINY-Breast03] The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In cases where clinical trial data and supporting documents are provided pursuant to our company policies and procedures, Daiichi Sankyo will continue to protect the privacy of our clinical trial participants. The DESTINY-Breast04 trial represents a new era of targeted therapies and has opened up treatment to a new HER2-low subset of breast cancer patients. DESTINY-Lung01 (NCT03505710) is an ongoing, multicentre, phase 2 study of trastuzumab deruxtecan in patients with non-squamous NSCLC overexpressing HER2 or containing a HER2-activating mutation. Official City of Calgary local government Twitter account. FDA approved a breakthrough treatment, Enhertu, for the treatment of HER2 low unresectable or metastatic breast cancer.
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