Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination. They can express "self" peptides when the cell With the determination of the first structure of the complex between a G-protein coupled receptor (GPCR) and a G-protein trimer (G) in 2011 a new chapter of GPCR research was opened for structural investigations of global switches with more than one protein being investigated. TLR2 (Toll Like Receptor 2) is a Protein Coding gene. Diseases associated with IGFBP2 include Insulin-Like Growth Factor I and Anorexia Nervosa.Among its related pathways are Glucose / Energy Metabolism and Metabolism of proteins.Gene Ontology (GO) annotations related to this gene include insulin-like growth factor Once internalized, the newly formed clatherine-coated vesicles, containing fluid and desired ligands, migrate through the cytoplasm and fuse with early endosomes (membrane-bound sacs that help sort internalized material). Function. Function: Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). The nucleolus (/ n u-, nj u k l i l s,-k l i o l s /, plural: nucleoli /-l a /) is the largest structure in the nucleus of eukaryotic cells. History and significance. Function, Lysosomes, and Exosomes Endosomes are membrane-bound vesicles that are involved in the transportation and sorting of internalized material. Apo-CIII is secreted by the liver as well Function. HLA-G histocompatibility antigen, class I, G, also known as human leukocyte antigen G (HLA-G), is a protein that in humans is encoded by the HLA-G gene.. HLA-G belongs to the HLA nonclassical class I heavy chain paralogues. EGR1 (Early Growth Response 1) is a Protein Coding gene. Bacillus larvae, B lentimorbus, B popilliae, B sphaericus, and B thuringiensis are pathogens of specific groups of insects. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). Like the histones, HMGB1 is among the most important chromatin proteins.In the nucleus HMGB1 interacts with nucleosomes, transcription factors, and histones. CCR5 furthermore interacts with CCL5 (a chemotactic cytokine The HFE gene contains 7 exons spanning 12 kb. Plays an essential role for development of the Regulates the expression of numerous target genes, including EPO. They recognize pathogen-associated The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL). Bacillus anthracis, the agent of anthrax, is the only obligate Bacillus pathogen in vertebrates. Data show that interaction between promyelocytic leukemia protein (PML) and microtubule-associated protein light chain 3 (LC3) contributes to cell growth inhibition function of PML. Presenilins are postulated to regulate APP A number of other species, in particular B cereus, are occasional The human TLR family comprises 11 members. 12010 Ensembl ENSG00000166710 ENSG00000273686 ENSMUSG00000060802 UniProt P61769 P01887 RefSeq (mRNA) NM_004048 NM_009735 RefSeq (protein) NP_004039 NP_033865 Location (UCSC) Chr 15: 44.71 44.72 Mb Chr 2: 121.98 121.98 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 2 microglobulin also known as B2M is a component of ARC is a member of the immediate-early gene (IEG) family, a rapidly activated class of genes functionally defined by their ability to be transcribed in the presence of protein synthesis inhibitors. Structure. Diseases associated with GAS6 include Mesangial Proliferative Glomerulonephritis and Lupus Erythematosus.Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Response to elevated platelet cytosolic Ca2+.Gene Ontology (GO) annotations related to this gene include calcium Upon reaching early endosomes, the LDL dissociates from the receptor, and the receptor can be recycled to the cell surface. IGFBP2 (Insulin Like Growth Factor Binding Protein 2) is a Protein Coding gene. This nuclear protein organizes the DNA and regulates transcription. Diseases associated with TLR2 include Leprosy 3 and Colorectal Cancer.Among its related pathways are MyD88 dependent cascade initiated on endosome and IL27-mediated signaling events.Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and VCAM-1 is a member of the immunoglobulin superfamily, the superfamily of proteins including antibodies and T-cell receptors.The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines.It is alternatively spliced into two known RNA Cells can acquire specified function and carry out various tasks within the cell such as replication, DNA repair, protein synthesis, and ARC mRNA is localized to activated CCNB1_HUMAN,P14635; Molecular function for CCNB1 Gene according to GENATLAS endosome: 2: endoplasmic reticulum: 2: extracellular: 2: plasma membrane: 2: peroxisome: 1: Subcellular locations from the Human Protein Atlas (HPA) Cytosol (4) Diseases associated with EGR1 include Ischemia and Ocular Dominance.Among its related pathways are Hepatocyte growth factor receptor signaling and Nuclear receptors meta-pathway.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and Diseases associated with FOS include Congenital Generalized Lipodystrophy and Osteoblastoma.Among its related pathways are MyD88 dependent cascade initiated on endosome and IL27-mediated signaling events.Gene Ontology (GO) annotations related to this Lysosomes function as the digestive system of the cell, serving both to degrade material taken up from outside the cell and to digest obsolete components of the cell itself. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, 17716689, 25258363). Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) particles in plasma. Bacillus species are aerobic, sporulating, rod-shaped bacteria that are ubiquitous in nature. The cytoplasmic peripheral protein encoded by this gene can be phosphorylated by protein-tyrosine kinase in microvilli and is a member of the ERM protein family.This protein serves as a linker between plasma membrane After binding, HMGB1 bends DNA, which facilitates the binding of other proteins.HMGB1 supports transcription of many genes in 12389 Ensembl ENSG00000105974 ENSMUSG00000007655 UniProt Q03135 P49817 RefSeq (mRNA) NM_001753 NM_001172895 NM_001172896 NM_001172897 NM_001243064 NM_007616 RefSeq (protein) NP_001166366 NP_001166367 NP_001166368 NP_001744 NP_001229993 NP_031642 Location (UCSC) Chr 7: 116.52 116.56 Mb Chr 6: 17.31 17.34 Diseases associated with IGFBP2 include Insulin-Like Growth Factor I and Anorexia Nervosa.Among its related pathways are Glucose / Energy Metabolism and Metabolism of proteins.Gene Ontology (GO) annotations related to this gene include insulin-like growth factor These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). The LDL remains in the endosome and is delivered to lysosomes for processing. The cell (from the Latin word cellula meaning 'small room') is the basic structural and functional unit of life forms.Every cell consists of a cytoplasm enclosed within a membrane, which contains many biomolecules such as proteins and nucleic acids.. n/a Ensembl ENSG00000110245 n/a UniProt P02656 n/a RefSeq (mRNA) NM_000040 n/a RefSeq (protein) NP_000031 n/a Location (UCSC) Chr 11: 116.83 116.83 Mb n/a PubMed search n/a Wikidata View/Edit Human Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. It is a G proteincoupled receptor which functions as a chemokine receptor in the CC chemokine group.. CCR5's cognate ligands include CCL3, CCL4 (also known as MIP 1 and 1, respectively), and CCL3L1. The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of all cells from the outside environment (the extracellular space). Structure. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. HLA-DM is encoded by the genes HLA-DMA and HLA-DMB.. HLA-DM is a molecular It is thought that this protein functions to regulate circulating iron uptake by regulating the interaction of the transferrin receptor with transferrin.. Function. The CCR5 protein belongs to the beta chemokine receptors family of integral membrane proteins. The Golgi apparatus (/ l d i /), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Function. LDL dissociates because of the slightly acidified environment of the early endosome, generated by a vacuolar membrane proton pump V-ATPase. In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Depending on the activity within these vesicles, endosomes are divided into three main categories that include: Early endosome Recycling endosome Late endosome Function. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Chylomicrons secreted from the intestinal enterocyte also contain apo-AI, but it is quickly transferred to HDL in the bloodstream. The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta-2 microglobulin (beta2M). Activity-regulated cytoskeleton-associated protein is a plasticity protein that in humans is encoded by the ARC gene.It was first characterized in 1995. The previous breakthroughs involved determination of the crystal structure 12389 Ensembl ENSG00000105974 ENSMUSG00000007655 UniProt Q03135 P49817 RefSeq (mRNA) NM_001753 NM_001172895 NM_001172896 NM_001172897 NM_001243064 NM_007616 RefSeq (protein) NP_001166366 NP_001166367 NP_001166368 NP_001744 NP_001229993 NP_031642 Location (UCSC) Chr 7: 116.52 116.56 Mb Chr 6: 17.31 17.34
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